Fig. 3

Survival analysis associated with single-cell membrane and secreting proteomics. A. Univariate survival analysis (Cox proportional hazards model) showing hazards ratio (HR) and 95% confidence interval (95%CI) of progression-free survival (PFS) time in 18-month follow-up, associated with single-cell membrane proteomics-defined cluster proportion (%) in each patient, with M0_low to M10_low indicating low %each cluster (e.g. M0_low indicates lower %cluster 0). B. Univariate survival analysis showing HR and 95% CI of PFS time, associated with single-cell secreting proteomics-defined cluster proportion in each patient, with S_0_low to S_8_low indicating low %each cluster (e.g. S_0_low indicates lower %cluster 0). C. Univariate survival analysis (Cox proportional hazards model) showing HR and 95% CI of clinicopathological covariates. D. Kaplan-Meier Survival curve stratified by median patient proportions of single-cell membrane proteomics-defined cluster 2 (M2). E. Multivariate survival analysis (Cox proportional hazards model) showing HR and 95% CI of PFS time, testing M_2_Low% as an independent variate adjusting for clinicopathological covariates. F. Kaplan-Meier Survival curve stratified by patient median proportions of single-cell secreting proteomics-defined cluster 2 (S_2). G. Multivariate survival analysis showing HR and 95% CI of PFS time (18-month follow-up), testing S_2_Low% as an independent variate adjusting for clinicopathological covariates