The association between tumor-stromal collagen features and the clinical outcomes of patients with breast cancer: a systematic review

Table 6 Association of collagen features of invasive breast tumors with T stage

Association	Collagen Feature	p-value	Comparison
Positive Association with T Stage	F/B ratio in Lobular Carcinoma	p < 0.05	T4 > T1-3	[54]
Positive Association with T Stage	Density	p = 0.003	T2 > T1	[58]
Negative Association with T Stage	COL1A1 Protein Expression	p = 0.04	T1 > T2 > T4 > T3	[10]
	Width	p < 0.0001	T1 > T2	[58]
	Length	p = 0.0006	T1 > T2	[58]
No Association with T Stage	COL1A1 mRNA Expression	NS	NS	[10]
	F/B Ratio in Ductal Carcinoma	NS	NS	[54]
	Straightness	NS	T1 = T2	[58]
	Angle	NS	T1 = T2	[58]

Definitions: F/B: (Higher value indicates larger fibril diameter, increased order in interfibrillar packing, and decreased fiber segmentation)
NS Not Significant, F/B the Forward-to-Backward ratio, COL1A1 Collagen Type I Alpha 1

ISSN: 1465-542X