The association between tumor-stromal collagen features and the clinical outcomes of patients with breast cancer: a systematic review

Table 8 Association of collagen features of invasive breast tumors with M stage

Association	Collagen Feature	p-value	Comparison	Reference
Negative Association with M Stage	Ln F/B	p = 0.004	NA	[27]
	Ln F/B	p < 0.005	NA	[56]
	Collagen Area Percentage	p = 0.0102	NA	[20]
	Collagen SHG Area Fraction	p = 0.0072	M0 > M1	[57]
No Association with M Stage	F/B Ratio	NS	NA	[54]
No Association with M Stage	Ln R2 value	NS	NA	[27]

Definitions: F/B: (Higher value indicates larger fibril diameter, increased order in interfibrillar packing, and decreased fiber segmentation). Ln R2 value: (higher values reflect greater anisotropy). Collagen SHG area fraction (Higher values indicate a greater collagen content within the tissue)
Abbreviations: NA Not Available, NS Not Significant, Ln R2 value Natural logarithm of the R-squared value, Ln F/B Natural logarithm of the Forward-to-Backward ratio

ISSN: 1465-542X