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Table 3 HRs and 95%CIs for the associations between, clinical depression, antidepressant use, and breast cancer risk; stratified by BMI category at Baseline

From: Depression, antidepressant use, and breast cancer incidence in the Sister Study cohort

 

Clinical Depression

Antidepressant Use

 

BMI < 25 kg/m2

BMI ≥ 25 kg/m2

BMI < 25 kg/m2

BMI ≥ 25 kg/m2

 

Exposed/Non-Exposed Cases

HR (95% CI)

Exposed/Non-Exposed Cases

HR (95% CI)

Het

Exposed/Non-Exposed Cases

HR (95% CI)

Exposed/Non-Exposed Cases

HR (95% CI)

Het

Overalla

272/1182

0.97 (0.85, 1.11)

645/1800

0.99 (0.91, 1.09)

0.87

213/1241

0.77 (0.66, 0.89)

577/1868

1.02 (0.92, 1.12)

 < 0.001

DCIS

62/283

0.94 (0.71, 1.25)

128/347

1.02 (0.83, 1.25)

0.72

49/296

0.74 (0.54, 1.01)

109/366

0.99 (0.79, 1.23)

0.17

Invasive

208/898

0.98 (0.84, 1.14)

516/1449

0.99 (0.89, 1.09)

0.91

164/942

0.78 (0.66, 0.92)

466/1499

1.02 (0.92, 1.14)

0.01

ER positiveb

164/675

1.02 (0.86, 1.21)

385/1068

1.00 (0.88, 1.12)

0.83

132/707

0.83 (0.69, 1.00)

358/1095

1.06 (0.94, 1.20)

0.03

ER negativeb

21/112

0.77 (0.47, 1.24)

60/181

0.88 (0.65, 1.18)

0.64

15/118

0.55 (0.32, 0.96)

54/187

0.90 (0.66, 1.23)

0.13

Overall Premenopausal

49/247

0.91 (0.66, 1.24)

77/217

1.02 (0.79, 1.33)

0.60

44/252

0.88 (0.63, 1.22)

74/220

1.13 (0.86, 1.49)

0.26

Overall Postmenopausal

223/935

0.99 (0.86, 1.15)

568/1583

0.99 (0.90, 1.09)

0.92

169/989

0.74 (0.63, 0.88)

503/1648

1.00 (0.90, 1.11)

 < 0.001

Invasive Premenopausal

33/189

0.78 (0.54, 1.14)

63/173

1.06 (0.79, 1.42)

0.22

31/191

0.80 (0.54, 1.17)

58/178

1.11 (0.82, 1.52)

0.20

Invasive Postmenopausal

175/709

1.03 (0.87, 1.21)

453/1276

0.98 (0.87, 1.09)

0.63

133/751

0.78 (0.64, 0.94)

408/1321

1.01 (0.90, 1.13)

0.02

  1. Abbreviations: DCIS ductal carcinoma in situ, ER estrogen receptor
  2. All models were adjusted for age, race/ethnicity, age at menarche, breastfeeding history, parity, menopausal status, any hormonal contraceptive use, hormone therapy type, oophorectomy status, physical activity level, smoking status, alcohol intake, mammogram in prior 2 years, alternative healthy eating index score, education level, annual household income per person, age at first birth, and family history of breast cancer
  3. Reference group: For the clinical depression models (women without a clinical depression diagnosis); for the antidepressant use models (non-users of antidepressants)
  4. aIncludes Invasive and DCIS breast cancer
  5. bn = 23 were excluded due to unknown ER status
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Breast Cancer Research

ISSN: 1465-542X

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